Your dog may need a supplement to make sure he’s getting the nutrients and calories needed to help his liver. LiverPak500 (paste) is veterinary formulated with key ingredients for your dog’s liver health including:
S-adenosylmethionine, Milk Thistle, Artichoke; Carnitine, Choline and Antioxidants.
S-adenosylmethionine : S-adenosylmethionine is a nucleotide-like molecule that is synthesised by all living cells. It is derived from methionine and ATP and initiates pathways, one of which is essential for glutathione production. S-adenosylmethionine : – Increases hepartic glutathione concentrations – Helps maintain plasma membrane fluidity and function – Is involved in many biochemical pathways that can help maintain normal liver cell function.
Choline : Choline plays an essential role in fat metabolism in the liver. It acts to prevent excess fat accumulations in the liver by converting excess fat into Lecithin or by increasing the utilisation of fatty acids in the liver. Artichoke : A member of the milk thistle family that helps control blood sugar levels, the artichoke is a fibrous, green vegetable containing cynarin. Cynarin is a phenolic acid compound that experts believe is important for cholagogue and choleretic properties; stimulating the production of bile in the liver and promoting the discharge of bile from the system.
Milk thistle has been used since the time of ancient physicians and herbalists to treat a range of liver and gallbladder disorders, including hepatitis, cirrhosis and jaundice, and to protect the liver against poisoning from chemical and environmental toxins, including snakebites, insect stings, mushroom poisoning, and alcohol (Ludvico, 2010). Several pharmacological studies have been carried out on the active components of Milk thistle, silymarin and silybinin. It has been found that these substances exert hepatoprotec-tive, antioxidant, anti-inflammatory and anti-fibrotic properties. In addition, they stimulate protein biosynthesis and liver regeneration, increase lactation and possess immunomodulation activity.
Carnitine : Carnitine is an amino acid derivative and nutrient involved in lipid (fat) metabolism in mammals. It is specifically required for the transport of fatty acids from the intermembraneous space in the mitochondria into the mitochondrial matrix during the catabolism of lipids.
Antioxidants : These play an essential role by controlling the oxidation of sensitive membranes. They ‘mop up’ destructive free radicals and protect cells from damage.
What causes liver disease in Dogs?
*Factors that increase your dog’s likelihood of developing liver disease include :
- Age : Several diseases, including liver dysfunction, are common in geriatric dogs.
- Breed : Certain dog breeds, such as Dobermans, Rottweilers, Yorkshire terriers and Cocker Spaniels, are more likely to be born with or are prone to develop particular liver problems.
- Some mediations can damage the liver in dogs as well as other factors such as:
- Viral and bacterial infections
- Poisonous substances your dog has eaten
- Altered blood flow to the liver due to heart disease or other congenital abnormality
*NSAIDs (non-steroidal anti-inflammatory drugs):
Special care of the dogs liver needs to be taken where NSAIDs are used. NSAIDs are the go-to medications for pain in dogs. Hundreds of thousands of dogs and cats receive millions of doses of these medications every year for pain relief after surgery, following traumatic events, and to manage chronic pain. They are especially used in older dogs with problems such as arthritis, but as with any drugs your dog may be fed, there are side-effects. Liver and gastrointestinal issues are by far the most common unwanted findings found when dosing your pet with NSAIDs.
Warning signs for Liver Disease
The signs of liver disease can be very similar to those of other conditions. If you notice any of the following signs in your dog, contact your veterinarian. Symptoms to look out for include:
– Poor or loss of appetite – Jaundice – Vomiting or diarrhea – Excessive drooling – Weight loss – Increased thirst – Changing in behaviour – Lack of energy or depression
Note: The signs of liver disease are not very specific, making it difficult to recognize. If your dog is not eating, consult your veterinarian immediately. The level of hepatic (liver) activity can be determined by evaluating liver enzymes through a blood test.